Beta-Nicotinamide Mononucleotide (β-NMN) is the biologically active form of NMN, crucial for boosting NAD+ levels, a coenzyme essential for cellular energy and longevity. Studies indicate that β-NMN has superior stability and absorption compared to other NMN forms.
Scientific Evidence Supporting Beta NMN’s Bioavailability:
🔬 Direct NAD+ Precursor
- β-NMN is efficiently converted into NAD+ in the body without requiring additional enzymatic steps, unlike Nicotinamide Riboside (NR), which first needs phosphorylation.
- Study: Research shows β-NMN is rapidly absorbed and converted into NAD+ in the bloodstream within 15 minutes of oral administration. (Mills et al., 2016)
🔬 Superior Gut Absorption
- β-NMN is absorbed via the Slc12a8 transporter in the small intestine, a pathway specialized for NMN uptake.
- Study: A 2019 study confirmed that the Slc12a8 transporter is highly selective for NMN, enabling efficient absorption and utilization. (Grozio et al., 2019)
🔬 Longer Circulating Half-Life
- Studies suggest β-NMN has a prolonged half-life in the bloodstream compared to free nicotinamide, ensuring sustained NAD+ elevation.
- Study: NMN supplementation in humans was shown to increase NAD+ levels for over 12 hours post-ingestion, making it a more effective NAD+ booster than standard niacin or nicotinamide. (Yoshino et al., 2021)
🔬 Targeted Cellular Uptake
- β-NMN bypasses metabolic bottlenecks seen with other NAD+ precursors, allowing for more efficient uptake into muscle, brain, and liver cells.
- Study: In a clinical trial, β-NMN supplementation led to a 38% increase in NAD+ levels in muscle tissues, improving mitochondrial function and reducing fatigue. (Imai & Guarente, 2016)
Conclusion
Beta NMN is the gold standard for NMN supplementation due to its high absorption rate, direct NAD+ conversion, and superior bioavailability. Delayed-release (DR) capsules further enhance its effectiveness by protecting NMN from degradation in the stomach, ensuring maximum cellular uptake and longevity benefits.
